BD: twice daily; CrCl: creatinine clearance; HF: heart failure; LVEF: left ventricular ejection fraction, MI: myocardial infarction; TIA: transient ischaemic attack; VKA: vitamin K antagonist. †Mean in RE-LY; median for ROCKET AF and ARISTOTLE. †† 35% in ROCKET AF; 40% for RE-LY and ARISTOTLE. †††Includes systemic embolism.