Interleukin-4 in the Generation of the AERD Phenotype: Implications for Molecular Mechanisms Driving Therapeutic Benefit of Aspirin Desensitization

<table class="table-group" id="tab3"><tr><td><table class="table"><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr class="thead"><td align="left"></td><td align="center">COX-1</td><td align="center">COX-2</td><td align="center">mPGES-1</td></tr><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr><td align="left">Monocytes</td><td align="center"><span style="width: 58.049999px;"><svg height="11.2875" id="M32" style="vertical-align:-0.3003pt" version="1.1" viewbox="0 0 58.049999 11.2875" width="58.049999" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,10.862)"><use xlink:href="#x31"></use></g><g transform="matrix(.017,-0,0,-.017,8.222,10.862)"><use xlink:href="#x2E"></use></g><g transform="matrix(.017,-0,0,-.017,12.098,10.862)"><use xlink:href="#x31"></use></g><g transform="matrix(.017,-0,0,-.017,24.031,10.862)"><use xlink:href="#xB1"></use></g><g transform="matrix(.017,-0,0,-.017,37.783,10.862)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,45.942,10.862)"><use xlink:href="#x2E"></use></g><g transform="matrix(.017,-0,0,-.017,49.818,10.862)"><use xlink:href="#x37"></use></g>
</svg></span></td><td align="center"><span style="width: 58.049999px;"><svg height="11.2875" id="M33" style="vertical-align:-0.3003pt" version="1.1" viewbox="0 0 58.049999 11.2875" width="58.049999" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg><sup>†</sup></span></td><td align="center"><span style="width: 58.049999px;"><svg height="11.2875" id="M34" style="vertical-align:-0.3003pt" version="1.1" viewbox="0 0 58.049999 11.2875" width="58.049999" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg><sup>†</sup></span></td></tr><tr><td align="left">Fibroblasts</td><td align="center"><span style="width: 58.049999px;"><svg height="11.4" id="M35" style="vertical-align:-0.3003pt" version="1.1" viewbox="0 0 58.049999 11.4" width="58.049999" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,10.963)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,8.222,10.963)"><use xlink:href="#x2E"></use></g><g transform="matrix(.017,-0,0,-.017,12.098,10.963)"><use xlink:href="#x36"></use></g><g transform="matrix(.017,-0,0,-.017,24.031,10.963)"><use xlink:href="#xB1"></use></g><g transform="matrix(.017,-0,0,-.017,37.783,10.963)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,45.942,10.963)"><use xlink:href="#x2E"></use></g><g transform="matrix(.017,-0,0,-.017,49.818,10.963)"><use xlink:href="#x37"></use></g>
</svg></span></td><td align="center"><span style="width: 58.049999px;"><svg height="11.2875" id="M36" style="vertical-align:-0.3003pt" version="1.1" viewbox="0 0 58.049999 11.2875" width="58.049999" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg><sup>†</sup></span></td><td align="center"><span style="width: 58.049999px;"><svg height="11.2875" id="M37" style="vertical-align:-0.3003pt" version="1.1" viewbox="0 0 58.049999 11.2875" width="58.049999" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg></span></td></tr><tr><td align="left">Eosinophils</td><td align="center"><span style="width: 58.049999px;"><svg height="11.4" id="M38" style="vertical-align:-0.3003pt" version="1.1" viewbox="0 0 58.049999 11.4" width="58.049999" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg></span></td><td align="center"><span style="width: 58.049999px;"><svg height="11.2875" id="M39" style="vertical-align:-0.3003pt" version="1.1" viewbox="0 0 58.049999 11.2875" width="58.049999" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg></span></td></tr><tr class="table-tr"><td colspan="4"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td>Quantitative polymerase chain reaction data, presented as fold change in comparison to unstimulated cells, which was set at 1. <sup>†</sup><svg height="11.375" id="M41" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 58.712502 11.375" width="58.712502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>.<br/></td></tr></table>

IL-4 modulation of PgE<sub>2</sub> metabolic pathway gene expression.

Journal of Allergy

tab3

Table 3

Table 3: Interleukin-4 in the Generation of the AERD Phenotype: Implications for Molecular Mechanisms Driving Therapeutic Benefit of Aspirin Desensitization 

Table 3 | Interleukin-4 in the Generation of the AERD Phenotype: Implications for Molecular Mechanisms Driving Therapeutic Benefit of Aspirin Desensitization 