International Scholarly Research Notices

Research Article

The Effect of Tempol Administration on the Aortic Contractile Responses in Rat Preeclampsia Model

Table 1

The effect of studied agents on aortic rings of different groups of animals ( 𝑛 = 8 − 1 0 ). pEC50, the negative logarithm of the concentrations of phenylephrine and calcium which produced half of maximal contraction. pIC50, the negative logarithm of concentrations of acetylcholine and diazoxide which relaxed 50 percent of the initial contraction.
GroupPhenylephrineCalciumAcetylcholineDiazoxide
pEC50Maximum contraction (mg)pEC50Maximum contraction (mg)pIC50Maximum relaxation (%)pIC50Maximum relaxation (%)
Normal 7 . 0 6 ± 0 . 1 1 † 6 6 0 ± 4 0 3 . 0 6 ± 0 . 0 4 2 7 0 ± 2 0 6 . 8 9 ± 0 . 1 1 # 8 6 ± 3 † 5 . 0 3 ± 0 . 1 2 9 8 ± 1
L-NAME (50 mg/kg) 7 . 6 1 ± 0 . 1 1 7 1 0 ± 4 0 3 . 1 2 ± 0 . 0 4 2 2 0 ± 2 0 5 . 9 3 ± 0 . 1 9 6 6 ± 5 4 . 9 0 ± 0 . 1 8 9 0 ± 4
L-NAME + tempol (20 mg/kg) 6 . 9 4 ± 0 . 1 0 † 3 6 0 ± 2 0 # 3 . 0 6 ± 0 . 0 9 3 2 0 ± 3 0 6 . 7 5 ± 0 . 2 5 ∗ 8 7 ± 5 † 5 . 0 3 ± 0 . 2 4 1 0 0 ± 0
L-NAME + tempol (60 mg/kg) 6 . 8 2 ± 0 . 2 5 † 4 4 0 ± 4 0 † 3 . 1 1 ± 0 . 1 0 3 4 0 ± 2 0 6 . 9 9 ± 0 . 2 1 † 9 1 ± 3 † 4 . 9 2 ± 0 . 1 2 9 9 ± 1
L-NAME + tempol (180 mg/kg) 7 . 0 8 ± 0 . 1 5 ∗ 6 1 0 ± 5 0 3 . 2 4 ± 0 . 0 7 5 5 0 ± 5 0 # 5 . 7 7 ± 0 . 1 5 7 6 ± 5 4 . 7 0 ± 0 . 0 7 8 7 ± 3
Values are means ± SEM. * 𝑃 < 0 . 0 5 ; † 𝑃 < 0 . 0 1 ; # 𝑃 < 0 . 0 0 1 .