Research Article
Encapsulation of Berberine in Nano-Sized PLGA Synthesized by Emulsification Method
Table 3
The berberine loading percentage onto PLGA nanoparticles prepared by different methods at pH 7.
| | S.N. | Synthesis method | Solvent used for loading drug | Surfactant used | Berberine added
| Particle size (nm) | % drug entrapment |
| | 1 | Single emulsion | Acetone | DMAB-0.3% | 1 mg | 1214 | 50 | | 2 | Single emulsion | Acetone | PVA-1% | 2 mg | 310 | 37.5 | | 3 | Single emulsion | DCM and acetone (4 : 1) | PVA-1% | 3 mg | 276 | 25 | | 4 | Double emulsion | DCM | PVA-1% | 1 mg | 182 | 30 | | 5 | Double emulsion | DCM and acetone (4 : 1) | PVA-1% | 1 mg | 298 nm | 40 |
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