Molecular Biology International

Research Article

Interleukin-1 Two-Locus Haplotype Is Strongly Associated with Severe Chronic Periodontitis among Yemenis

Table 4

IL-1B C T allele frequency, genotype distribution, and HWE status in the cases and controls.
ParameterOverall Cases Controls OR (95% CI)
Dominant modelAdditive modelRecessive model
C allele90 (56.2%)42 (52.5%)48 (60.0%)—a 
T allele70 (43.8%)38 (47.5%)32 (40.0%)4.20 (0.37–48.0)b 
CC genotype22 (27.5%)12 (30.0%)10 (25.0%)   
TC genotype46 (57.5%)18 (45.0%)28 (70.0%)1.05 (0.02–60.0)7.38 (0.45–121)461 (2.80–7.5E4)*
TT genotype12 (15.0%)10 (25.0%)02 (05.0%)   
HWEc++−N/A 
OR: odds ratio in the cases compared to the controls; logistic regression adjusting for mean plaque index (MPI) and MPI-genotype interaction.
aReference category.
bModels are not applicable.
cHWE: Hardy-Weinberg equilibrium; (+): consistent with; (−): significant deviation.
* .