Interleukin-1 Two-Locus Haplotype Is Strongly Associated with Severe Chronic Periodontitis among Yemenis

<table class="table-group" id="tab5"><tr><td><table class="table"><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr class="thead"><td align="left">Statistic</td><td align="center">Overall</td><td align="center">Cases <svg height="11.125" id="M39" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 44.400002 11.125" width="44.400002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,10.862)"><use xlink:href="#x1D45B"></use></g><g transform="matrix(.017,-0,0,-.017,13.305,10.862)"><use xlink:href="#x3D"></use></g><g transform="matrix(.017,-0,0,-.017,28.008,10.862)"><use xlink:href="#x34"></use></g><g transform="matrix(.017,-0,0,-.017,36.168,10.862)"><use xlink:href="#x30"></use></g>
</svg></td><td align="center">Controls <svg height="11.125" id="M40" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 44.400002 11.125" width="44.400002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,10.862)"><use xlink:href="#x1D45B"></use></g><g transform="matrix(.017,-0,0,-.017,13.305,10.862)"><use xlink:href="#x3D"></use></g><g transform="matrix(.017,-0,0,-.017,28.008,10.862)"><use xlink:href="#x34"></use></g><g transform="matrix(.017,-0,0,-.017,36.168,10.862)"><use xlink:href="#x30"></use></g>
</svg></td></tr><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr><td align="left">Disequilibrium coefficient (D<sup>′</sup>)</td><td align="center">0.62</td><td align="center">0.80</td><td align="center">0.44</td></tr><tr><td align="left">Correlation coefficient (<svg height="16.049999" id="M41" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 13.6375 16.049999" width="13.6375" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,15.775)"><path d="M393 379q-9 -16 -28 -29q-15 -10 -23 -2q-19 19 -36 19q-21 0 -52 -38q-57 -72 -82 -126l-40 -197q-23 -3 -75 -18l-7 7q49 196 74 335q7 43 -2 43q-7 0 -30 -14.5t-47 -37.5l-16 23q37 42 82 73t67 31q41 0 15 -113l-11 -50h4q41 71 85 117t77 46q29 0 45 -26
q13 -21 0 -43z" id="x1D45F"></path></g>
<g transform="matrix(.012,-0,0,-.012,7.238,7.613)"><use xlink:href="#x32"></use></g>
</svg>)</td><td align="center">0.34</td><td align="center">0.47</td><td align="center">0.18</td></tr><tr><td align="left">Log of likelihood odds ratio (LOD)</td><td align="center">&gt;2</td><td align="center">&gt;2</td><td align="center">&lt;2</td></tr><tr class="table-tr"><td colspan="4"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td><sup>
									*</sup>Statistically significant when &gt;2. <br/></td></tr></table>

IL-1A C<svg height="14.85" id="M37" style="vertical-align:-2.22495pt" version="1.1" viewbox="0 0 46.3125 14.85" width="46.3125" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,12.012)"><use xlink:href="#x5B"></use></g><g transform="matrix(.017,-0,0,-.017,5.927,12.012)"><use xlink:href="#x2212"></use></g><g transform="matrix(.017,-0,0,-.017,15.905,12.012)"><use xlink:href="#x38"></use></g><g transform="matrix(.017,-0,0,-.017,24.065,12.012)"><use xlink:href="#x38"></use></g><g transform="matrix(.017,-0,0,-.017,32.224,12.012)"><use xlink:href="#x39"></use></g><g transform="matrix(.017,-0,0,-.017,40.384,12.012)"><use xlink:href="#x5D"></use></g>
</svg>T and IL-1B C<svg height="14.85" id="M38" style="vertical-align:-2.22495pt" version="1.1" viewbox="0 0 44.487499 14.85" width="44.487499" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,12.012)"><use xlink:href="#x5B"></use></g><g transform="matrix(.017,-0,0,-.017,5.927,12.012)"><use xlink:href="#x33"></use></g><g transform="matrix(.017,-0,0,-.017,14.086,12.012)"><use xlink:href="#x39"></use></g><g transform="matrix(.017,-0,0,-.017,22.246,12.012)"><use xlink:href="#x35"></use></g><g transform="matrix(.017,-0,0,-.017,30.405,12.012)"><use xlink:href="#x34"></use></g><g transform="matrix(.017,-0,0,-.017,38.565,12.012)"><use xlink:href="#x5D"></use></g>
</svg>T linkage disequilibrium analysis.   

Molecular Biology International

tab5

Table 5

Table 5: Interleukin-1 Two-Locus Haplotype Is Strongly Associated with Severe Chronic Periodontitis among Yemenis 