Research Article
Interleukin-1 Two-Locus Haplotype Is Strongly Associated with Severe Chronic Periodontitis among Yemenis
Table 6
IL-1 two-locus haplotype analysis.
| | Haplotype | Bi-allelic | Cases | Controls | OR¶ (95% CI) | | Dominant model | Additive model | Recessive model |
| | O/O | 14 (35.0%) | 08 (20.0%) | | | | | C-C | C-C/O | 19 (47.5%) | 26 (65.0%) | 0.31 (0.08–1.17) | 0.86 (0.36–2.09) | 4.03 (0.77–21.2) | | C-C/C-C | 07 (17.5%) | 06 (15.0%) | | | |
| | O/O | 37 (92.5%) | 30 (75.0%) | | | | | C-T | C-T/O | 03 (07.5%) | 09 (22.5%) | 0.16 (0.03–0.85)* | 0.17 (0.03–0.83)* | 0.72 (0.00–28.0) | | C-T/C-T | 00 (00.0%) | 01 (02.5%) | | | |
| | O/O | 32 (80.0%) | 30 (75.0%) | | | | | T-C | T-C/O | 07 (17.5%) | 10 (25.0%) | 0.92 (0.24–3.50) | 0.93 (0.25–3.50) | 0.04 (0.001–INF) | | T-C/T-C | 01 (02.5%) | 00 (00.0%) | | | |
| | O/O | 13 (32.5%) | 19 (47.5%) | | | | | T-T | T-T/O | 19 (47.5%) | 21 (52.5%) | 1.73 (0.54–5.56) | 2.55 (0.95–6.87) | 15.6 (1.58–INF)* | | T-T/T-T | 08 (20.0%) | 00 (00.0%) | | | |
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O: other haplotype.
¶OR: odds ratio in the cases compared to the controls; logistic regression adjusting for mean plaque index.
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