Journal of Allergy

Review Article

How Can Microarrays Unlock Asthma?

Table 4

The GEO accession number for microarray studies conducted on asthma.
YearTitleArrayGEO accession numberReference
Smooth muscle cells
2001Interleukin-13 induces dramatically different transcriptional programs in three human airway cell typesAffymetrix Hugene FLn/a[21]
2004Effects of interleukin-1 [beta], interleukin-13, and transforming growth factor-[beta] on gene expression in human airway smooth muscle using gene microarraysAffymetrix GeneChip 95An/a[23]
2005The effect of IL13 and IL13R130Q, a naturally occurring IL13 polymorphism, on the gene expression of human airway smooth muscle cells8159 human gene cDNA clones from Research Genetics (IMAGE consortium, Huntsville, AL), Incyte Genomicsn/a[24]
20071α,25-Dihydroxy-vitamin D3 stimulation of bronchial smooth muscle cells induces autocrine, contractility, and remodeling processesHuman Genome U133 Plus 2.0 GeneChip arraysGSE5145[26]
2009Glucocorticoid- and protein kinase A-dependent transcriptome regulation in airway smooth muscleAffymetrix Human U133A DNA microarraysGSE13168[25]
2010MicroRNA expression in human airway smooth muscle cells: role of miR-25 in regulation of airway smooth muscle phenotypemirVana miRNA bioarrays V2 (Ambion)GSE16587 GSE16586[67]
Epithelial cells
2002Analysis of novel disease-related genes in bronchial asthmaAffymetrix Hugene FLn/a[34]
2003Respiratory syncytial virus infection activates STAT signaling in human epithelial cellsAffymetrix Hugene FLn/a[35]
2006Induction of the plasminogen activator system by mechanical stimulation of human bronchial epithelial cellsAffymetrix Human 133A DNA microarraysn/a[36]
2007IL-13 and epidermal growth factor receptor have critical but distinct roles in epithelial cell mucin productionUCSF 9Hs Human 23K v.2 Oligo ArrayGSE4804[37]
2007Genomewide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroidsHuman Genome U133 Plus 2.0 GeneChip arraysGSE4302[41]
2009Airway epithelial cells regulate the functional phenotype of locally differentiating dendritic cells: implications for the pathogenesis of infectious and allergic airway diseaseHuman Genome U133 Plus 2.0 GeneChip arraysGSE12773[38]
2009T-helper type 2-driven inflammation defines major subphenotypes of asthmaHuman Genome U133 Plus 2.0 GeneChip arraysGSE4302[39]
2010Rhinovirus-induced modulation of gene expression in bronchial epithelial cells from subjects with asthmaHuman Genome Focus GeneChip Array
Human Genome U133 Plus 2.0 GeneChip arrays		GSE13396[40]
2010Transglutaminase 2, a novel regulator of eicosanoid production in asthma revealed by genomewide expression profiling of distinct asthma phenotypesAffymetrix Human U133A DNA microarrays
Human Genome U133 Plus 2.0 GeneChip arrays		GSE13785[83]
2010Decreased fibronectin production significantly contributes to dysregulated repair of asthmatic epitheliumAffymetrix Human 133A DNA microarraysGSE18965[42]
Mast Cells
2001Gene expression screening of human mast cells and eosinophils using high-density oligonucleotide probe arrays: abundant expression of major basic protein in mast cellsAffymetrix GeneChip 95An/a[51]
2005Amphiregulin expression in human mast cells and its effect on the primary human lung fibroblastsAffymetrix Genechip Human Genome U133n/a[52]
2009Human mast cells synthesize and release angiogenin, a member of the ribonuclease A (RNase A) superfamilyNIAID (human sequence chip series “sa”) and consist of 13,971 oligonucleotides, synthesized by Qiagen Operon Inc. (Valencia, CA, USA)n/a[53]
Tissue
2004Functional classes of bronchial mucosa genes that are differentially expressed in asthmaAffymetrix GeneChip 95AGSE15823[22]
2010Gene transcription changes in asthmatic chronic rhinosinusitis with nasal polyps and comparison to those in atopic dermatitisAffymetrix HuExon 1.0 STGSE5667[63]
GEO: NCBI Gene Expression Omnibus.
n/a: microarray data not submitted to a database or not stated in paper.