International Scholarly Research Notices

Review Article

Prognostic Significance of Vascular Endothelial Growth Factor Serum Determination in Women with Ovarian Cancer

Table 3

Univariate and multivariate analyses for overall survival.
VariableAuthor, yearNo. casesCut-offUnivariate analysis RR or HR, 𝑃 - v a l u e Multivariate analysis RR or HR, 𝑃 - v a l u e
VEGF (pg/mL)Tempfer et al., 1998 [21]60β‰₯826 versus <826 R R = 2 . 7 , 𝑃 = 0 . 0 0 7 R R = 2 . 7 , 𝑃 = 0 . 0 0 8
Gadducci et al., 1999 [22]53NA 𝑃 = N S NA
Chen et al., 1999 [23]56NA 𝑃 < 0 . 0 0 1 / 𝑃 = 0 . 0 0 6 βˆ— R R = 4 . 4 7 , 𝑃 ≀ 0 . 0 0 1 ; R R = 5 . 3 7 βˆ— , 𝑃 < 0 . 0 0 1 βˆ—
Oehler and Caffier, 2000 [24]41β‰₯440 versus <440 H R = 3 . 5 6 , 𝑃 = 0 . 0 2 6 𝑃 = N S
Cooper et al., 2002 [25]101β‰₯380 versus <380 H R = 2 . 1 3 , 𝑃 = 0 . 0 0 9 H R = 2 . 0 8 , 𝑃 = 0 . 0 2
Li et al., 2004 [26]50β‰₯100 versus <100 𝑃 = 0 . 0 0 8 5 ; 𝑃 = 0.4Β§ ; 𝑃 = 0 . 0 2 ∧ 𝑃 = 0 . 0 7 5 0
Harloziňska et al., 2004 [27]86β‰₯750 versus <750 𝑃 = 0 . 0 1 6 9 R R = 2 . 3 5 ; 𝑃 = 0 . 0 2
Hefler et al., 2006 [28]314continuous variable 𝑃 < 0 . 0 0 1 ; 𝑃 < 0 . 0 0 1 ∘ H R = 1 . 8 , 𝑃 = 0 . 0 3 ; H R = 1 . 1 ∘ , 𝑃 = 0 . 0 0 1 ∘
Mahner et al., 2010 [29]37171 𝑃 = 0 . 3 0 2 NA
StageTempfer et al., 1998 [21]60I/II versus III/IV R R = 3 . 2 , 𝑃 = 0 . 0 0 7 R R = 3 . 2 , 𝑃 = 0 . 0 0 1
Chen et al., 1999 [23]56I/II versus III/IVNA R R = 2 . 0 8 , 𝑃 = 0 . 1 1 ; R R = 3 . 8 4 βˆ— , 𝑃 = 0 . 0 1 βˆ—
Oehler and Caffier, 2000 [24]41I/II versus III/IV H R = 2 . 2 4 , 𝑃 = 0 . 0 4 3 𝑃 = N S
Cooper et al., 2002 [25]101I/II versus III/IV H R = 1 0 . 1 5 , 𝑃 < 0 . 0 0 1 H R = 9 . 2 4 , 𝑃 < 0 . 0 0 1
Li et al., 2004 [26]50NANA 𝑃 = N S
Harloziňska et al., 2004 [27]86I/II versus III/IV 𝑃 = 0 . 0 0 0 6 R R = 4 . 0 8 , 𝑃 = 0 . 0 0 8
Hefler et al., 2006 [28]314NA 𝑃 < 0 . 0 0 1 H R = 1 . 7 , 𝑃 < 0 . 0 0 1
GradeTempfer et al., 1998 [21]60G1 versus G2/3 R R = 1 . 4 , 𝑃 = 0 . 0 0 5 R R = 1 . 4 , 𝑃 = 0 . 0 1
Chen et al., 1999 [23]56G1 versus G2/3NA R R = 2 . 3 8 , 𝑃 = 0 . 0 3 4 ; R R = 2 . 4 4 βˆ— , 𝑃 = 0 . 0 4 5 βˆ—
Cooper et al., 2002 [25]101G1/2 versus G3 H R = 1 . 3 6 , 𝑃 = 0 . 2 9 H R = 0 . 8 6 ; 𝑃 = 0 . 6 3
Li et al., 2004 [26]50NANA 𝑃 = N S
Harloziňska et al., 2004 [27]86G1 versus G2/3 𝑃 = 0 . 0 0 0 7 9 𝑃 = N S
Hefler et al., 2006 [28]314NA 𝑃 < 0 . 0 0 1 ; 𝑃 = 0 . 2 ∘ H R = 1 . 2 , 𝑃 = 0 . 3 ; H R = 3 . 4 ∘ , 𝑃 = 0 . 0 2 ∘
Residual tumor size (cm)Chen et al., 1999 [23]56β‰₯2 versus <2NA R R = 1 . 3 4 , 𝑃 = 0 . 4 6
Oehler and Caffier, 2000 [24]410 versus 1 + 2 H R = 1 1 . 6 8 , 𝑃 = 0 . 0 1 8 H R = 1 1 . 6 8 , 𝑃 = 0 . 0 1 8
Cooper et al., 2002 [25]1010 versus 1 + 2 H R = 2 . 2 , 𝑃 = 0 . 0 0 7 H R = 1 . 2 9 , 𝑃 = 0 . 4 2
Li et al., 2004 [26]50NANA 𝑃 = 0 . 0 1 9
Harloziňska et al., 2004 [27]86β‰₯2 versus <2 𝑃 = 0 . 0 0 6 3 7 𝑃 = N S
Hefler et al., 2006 [28]314β‰₯1 versus <1 𝑃 < 0 . 0 0 1 H R = 1 . 8 , 𝑃 = 0 . 0 0 6
Lymph node involvementTempfer et al., 1998 [21]60Yes versus No R R = 2 . 8 , 𝑃 = 0 . 0 0 0 7 R R = 2 . 8 , 𝑃 = 0 . 0 0 6
Li et al., 2004 [26]50NANA 𝑃 = N S
Histological typeChen et al., 1999 [23]56serous/mucinous versus othersNA R R = 0 . 9 9 , 𝑃 = 0 . 9 2 ; R R = 1 . 1 4 βˆ— , 𝑃 = 0 . 2 1 βˆ—
Li et al., 2004 [26]50NANA 𝑃 = N S
Harloziňska et al., 2004 [27]86serous versus others 𝑃 = N S 𝑃 = N S
Hefler et al., 2006 [28]314serous versus others 𝑃 = 0 . 3 ; 𝑃 = 0 . 6 ∘ H R = 1 . 1 , 𝑃 = 0 . 6 ; H R = 1 ∘ , 𝑃 = 0 . 9 ∘
AscitesCooper et al., 2002 [25]101presence versus absence H R = 2 . 5 , 𝑃 = 0 . 0 0 4 H R = 1 . 2 8 , 𝑃 = 0 . 5 4
Age (years)Oehler and Caffier 2000 [24]41β‰₯60 versus <60 𝑃 = N S 𝑃 = N S
Cooper et al., 2002 [25]101NA H R = 1 . 3 4 , 𝑃 = 0 . 3 0 H R = 1 . 1 6 , 𝑃 = 0 . 6 3
Harloziňska et al., 2004 [27]86β‰₯62 versus <62 𝑃 = 0 . 0 4 7 8 R R = 2 . 2 0 , 𝑃 = 0 . 0 2 7 2
Hefler et al., 2006 [28]314continuous variable 𝑃 = 0 . 0 1 , 𝑃 = 0 . 8 ∘ H R = 1 , 𝑃 = 0 . 9 ; H R = 1 ∘ , 𝑃 = 0 . 6 ∘
*:Subset of 40 patients with residual tumour size ≀2 cm; Β°:Subset of 56 patients with stage I; Β§:Subset of patients with stages I-II; ∧:Subset of patients with stages III-IV; NA: not available data; NS: non-significant statistical analysis.