Review Article

Prognostic Significance of Vascular Endothelial Growth Factor Serum Determination in Women with Ovarian Cancer

Table 4

Univariate and multivariate analyses for disease free survival.

VariableAuthor, yearNo. casesCut-offUnivariate analisys RR, ๐‘ƒ - v a l u e Multivariate analisys RR, ๐‘ƒ - v a l u e

Tempfer et al., 1998 [21]60โ‰ฅ826 versus <826 R R = 1 . 8 , ๐‘ƒ = 0 . 0 0 3 R R = 1 . 8 , ๐‘ƒ = 0 . 0 2
VEGF (pg/mL)Chen et al., 1999 [23]56NA ๐‘ƒ = 0 . 0 0 1 , ๐‘ƒ = 0 . 0 0 1 โˆ— R R = 3 . 3 4 , ๐‘ƒ = 0 . 0 0 2 ; R R = 5 . 6 2 โˆ— , ๐‘ƒ < 0 . 0 0 1 โˆ—
Harloziลˆska et al., 2004 [27]314โ‰ฅ750 versus <750 ๐‘ƒ = N S ๐‘ƒ = N S

StageTempfer et al., 1998 [21]60I/II versus III/IV R R = 1 . 3 , ๐‘ƒ = 0 . 0 1 R R = 1 . 3 , ๐‘ƒ = 0 . 0 2
Chen et al., 1999 [23]56I/II versus III/IVNA R R = 2 . 0 9 , ๐‘ƒ = 0 . 1 0 ; R R = 3 . 2 8 โˆ— , ๐‘ƒ = 0 . 0 2 7 โˆ—
Harloziลˆska et al., 2004 [27]314I/II versus III/IV ๐‘ƒ = 0 . 0 0 0 R R = 4 . 6 6 , ๐‘ƒ = 0 . 0 0 0 1 8

GradeTempfer et al., 1998 [21]60G1 versus G2/G3 R R = 1 . 9 , ๐‘ƒ = 0 . 0 3 R R = 1 . 9 , ๐‘ƒ = 0 . 0 4
Chen et al., 1999 [23]56G1 versus G2/G3NA R R = 2 . 2 4 , ๐‘ƒ = 0 . 0 4 2 ; R R = 2 . 5 5 โˆ— , ๐‘ƒ = 0 . 0 3 7 โˆ—
Harloziลˆska et al., 2004 [27]314G1 versus G2/G3 ๐‘ƒ = 0 . 0 0 0 1 ๐‘ƒ = N S

Residual tumour sizeChen et al., 1999 [23]56โ‰ฅ2 versus <2NA R R = 0 . 9 6 , ๐‘ƒ = 0 . 9 3
Harloziลˆska et al., 2004 [27]314โ‰ฅ2 versus <2 ๐‘ƒ = 0 . 0 0 0 1 ๐‘ƒ = N S

Lymph node involvementTempfer et al., 1998 [21]60Yes versus No R R = 2 . 8 , ๐‘ƒ = 0 . 0 0 9 R R = 2 . 8 , ๐‘ƒ = 0 . 0 0 9

Histological typeChen et al., 1999 [23]56serous/mucinous versus othersNA R R = 0 . 9 7 , ๐‘ƒ = 0 . 7 3 ; R R = 1 . 0 4 โˆ— , ๐‘ƒ = 0 . 7 โˆ—
Harloziลˆska et al., 2004 [27]314serous versus others ๐‘ƒ = N S ๐‘ƒ = N S

Age (years)Harloziลˆska et al., 2004 [27]314โ‰ฅ62 versus <62 ๐‘ƒ = N S ๐‘ƒ = N S

*:Subset of 40 patients with residual tumour size โ‰ค2โ€‰cm; NA: not available data; NS: non-significant statistical analysis.