Research Article
Application of HPLC for the Simultaneous Determination of Paracetamol, Chlorzoxazone, and Nimesulide in Pharmaceutical Dosage Form
Table 5
Accuracy studies for the determination of PCM, CHZ and NIM (
).
| | | Excess drug added to the analyte (%) | Theoretical Content (g mL−1) | Measured conc. ± SD | Recovery (%) | % R.S.D. | S.E. |
| PCM
| 80
| 40.95
| 41.27 ± 0.37
| 100.78
| 0.89 | 0.36 | 100
| 45.50
| 45.10 ± 0.45
| 99.12
| 0.99 | 0.40 | 120
| 50.05
| 49.95 ± 0.25
| 99.80
| 0.50 | 0.21 |
| CHZ
| 80
| 47.25
| 47.45 ± 0.85
| 100.04
| 1.79 | 0.73 | 100
| 52.50
| 52.15 ± 0.97
| 99.33
| 1.86 | 0.76 | 120
| 57.75
| 58.05 ± 0.75
| 100.50
| 1.29 | 0.53 |
| NIM
| 80
| 12.60
| 12.55 ± 0.15
| 99.60
| 1.19 | 0.49 | 100
| 14.00
| 14.05 ± 0.25
| 100.35
| 1.77 | 0.72 | 120
| 15.40
| 15.25 ± 0.10
| 99.02
| 0.65 | 0.27 |
|
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