Future perspectives and new lines of research. Representation of perspectives and new lines of research. (a) Demonstration of factors involved in senescence induction in the lungs and susceptibility to pulmonary fibrosis and bacterial infection. (b) Consequences of pneumococcal infection lead to increased inflammation, and toxic bacterial products transmitted through the blood vessels cause cardiomyocyte toxicity. In addition, paracrine effect of SASP cells may increase PAFr production and contribute to endothelial cell senescence in the cardiac tissue, resulting in adverse cardiac events.