AKT/mTOR as Novel Targets of Polyphenol Piceatannol Possibly Contributing to Inhibition of Proliferation of Cultured Prostate Cancer Cells
Figure 4
A model mechanism on the ability of piceatannol to induce apoptosis and suppress cell proliferation in CaP cells is proposed. (a) For induction of apoptosis, the effects of piceatannol is postulated to occur secondary to DNA damage accompanied by increased phosphorylation of H2AX at Ser139, which facilitate and culminate in the cleavage of caspase 3 and AIF. (b) for suppression of proliferation, piceatannol is proposed to inhibit the AKT/mTOR signaling pathway resulting in suppression of CaP cell proliferation and survival.
