Neural Circuit in the Dorsal Raphe Nucleus Responsible for Cannabinoid-Mediated Increases in 5-HT Efflux in the Nucleus Accumbens of the Rat Brain
Figure 3
Effect of reverse dialysis infusion of WIN 55,212-2 on 5-HT efflux in the DRN (a) or NAcc (b). Data are expressed as percent of average baseline values (% mean ± s.e.m.). Note that 1 μM citalopram was included in the infusion medium. Mean baseline level of extracellular 5-HT was pg/sample in the DRN () and pg/sample in the NAcc (). The open horizontal bars indicate the 30-min period of drug infusion. (a) WIN 55,212-2 (100, 300 and 1000 μM) produced a concentration-dependent increase in 5-HT efflux in the DRN. (b) WIN 55,212-2 (100, 300, and 1000 μM) produced a concentration-dependent decrease in 5-HT efflux in the NAcc. *, ** and *** versus vehicle examined by the repeated measures ANOVA followed by post hoc Scheffe test.
