Table 2: Expression of ECM proteins/integrin ligands, their potential crosstalk with G proteins and change in expression in disease.

ECM/integrin ligandsPotential crosstalk with G proteinsDiseaseReference

Cyr61G12/13 ↑ in breast and endometrial cancers
RGD sequence in P2Y2 receptor
Laminin-111 Gi, and Gs ↑ in asthma
Fibronectin Gq and G12/13 ↑ in asthma[4750]
Collagen I Gq ↑ in asthma[47, 48, 51]
Collagen VGi and Gs ↑ in asthma

n.d.: not determined.