International Scholarly Research Notices

Research Article

Response Surface Optimization of Sustained Release Metformin-Hydrochloride Matrix Tablets: Influence of Some Hydrophillic Polymers on the Release

Table 2

Evaluation of granules.

Sl. no.		Batch codeEvaluating parameters
Angle of reposeBulk densityTapped densityCarr’s indexHausner’s ratio
1FF1 3 1 . 2 3 ± 0 . 0 7 0 . 5 9 3 ± 0 . 0 2 0 . 7 0 1 ± 0 . 0 6 1 5 . 4 1 ± 0 . 0 8 1.18
2FF2 3 0 . 8 9 ± 0 . 0 8 0 . 5 6 1 ± 0 . 0 7 0 . 6 7 3 ± 0 . 0 3 1 6 . 6 4 ± 0 . 1 1 1.2
3FF3 2 9 . 1 6 ± 0 . 1 1 0 . 4 9 7 ± 0 . 0 4 0 . 6 0 7 ± 0 . 0 7 1 8 . 1 2 ± 0 . 0 7 1.22
4FF4 3 0 . 7 2 ± 0 . 0 6 0 . 4 8 2 ± 0 . 0 6 0 . 5 7 3 ± 0 . 0 2 1 5 . 7 3 ± 0 . 0 9 1.19
5FF5 3 1 . 5 2 ± 0 . 1 3 0 . 5 3 2 ± 0 . 0 9 0 . 6 1 3 ± 0 . 0 8 1 3 . 2 1 ± 0 . 1 4 1.15
6FF6 3 2 . 6 9 ± 0 . 1 4 0 . 5 1 3 ± 0 . 0 8 0 . 6 2 9 ± 0 . 0 5 1 8 . 4 4 ± 0 . 1 3 1.23
All values represent mean ± SD ( 𝑛 = 3 ).