Research Article

A Robust Topology-Based Algorithm for Gene Expression Profiling

Figure 4

(a) The heat map for the bisection of GBM patient samples with red (resp., green) representing fold inductions higher (resp., lower) than the mean. The horizontal blue line separates the gene groups and , while the vertical line partitions the two components of patient samples. The patient samples are arranged (left to right) in the order they join each component. It is clear that samples joining a component later are less tightly correlated to the group. (b) The heat map for the core patient samples in each component using genes in and . Component A contains classical and mesenchymal patient samples, while B contains proneural samples.
381023.fig.004a
(a)
381023.fig.004b
(b)