Research Article
Use of Charge Transfer Complexation Reactions for the Spectrophotometric Determination of Sumatriptan in Pharmaceuticals
Table 1
Comparison of the proposed and the existing visible spectrophotometric methods.
| | Sl. no. | Reagent/s | , nm | Beer’s law range, g mL−1
( in l mol−1 cm−1) | Remarks |
Reference |
| | | Bromate-bromide- | | | | | | 1 | (a) methyl orange, | 508 | 0.2–1.6
(1.90 × 105) | Multistep reaction, time consuming | [28] | | | (b) indigo carmine | 610 | 2.0–12.0
(2.71 × 104) | | |
| | 2 | Folin-Ciocalteu reagent | 760 | 2.0–6.0
— | Multi step reaction | [22] |
| | 3
| (a) Quinone | 548 | 5.0–25.0
(1.00 × 104) | Involves heating step, time consuming
|
[29]
| | (b) acetaldehyde with p-chloranil | 660 | 20.0–60.0
(3.19 × 104) |
| | 4 | Sodium nitroprusside acetaldehyde | 552 | 4.0–20.0
(1.10 × 104) | Requires rigid pH control | [30] |
| | 5
| (a) Brucine-sodium metaperiodate, | 520 | 4.0–20.0
— |
Multi step reaction |
[31]
| | (b) citric acid-acetic anhydride | 580 | 8.0–24.0
— |
| | 6 | Folin reagent | 455.6 | 16.0–48.0
(3.85 × 103) | Strict pH control, time consuming | [32] |
| | 7 | Cobalt thiocyanate | 629.4 | 16.0–48.0
(3.97 × 103) | Involves extraction step | [33] |
| | 8 | Tropaeolin-OOO | 482.5 | 2.0–10.0
(2.08 × 104) | Requires rigid pH control; involves liquid-liquid extraction | [34] |
| | 9 | p-Chloranilic acid | 520 | 9.28 × 102 | — | [37] |
| |
10
|
(a) 2,3-dichloro-5,6-dicyano-1,4-benzoquinone,
|
585
|
4.0–56.0
(4.77 ×
)
| Single step reaction, no heating or extraction step, or use of single reagent | Present methods | |
(b) iodine
|
375
|
2.0–28.0
(9.56 ×
)
|
|
|
