Use of Charge Transfer Complexation Reactions for the Spectrophotometric Determination of Sumatriptan in Pharmaceuticals
Table 4
Robustness and ruggedness.
Method
SMT taken, g mL−1
Method robustness
Method ruggedness
Parameters altered
Reagent volume, mLa RSD, % ()
Reaction timeb RSD, % ()
Interanalysts RSD, % ()
Intercuvettes RSD, % ()
DDQ method
16.0
1.23
0.93
1.56
1.34
32.0
0.89
1.15
1.31
1.47
48.0
1.11
1.49
1.78
1.50
I2 method
8.00
1.02
0.85
1.40
1.29
16.0
1.18
1.32
1.63
1.09
24.0
1.40
1.28
1.75
1.13
aIn both methods, the volume of reagent was 0.8, 1.0, and 1.2 mL. bThe reaction time was 4, 5, and 6 min in DDQ method and 9, 10, and 11 min in I2 method.
