Combination Phototherapy with a Histone Deacetylase Inhibitor and a Potent DNA-Binding Bibenzimidazole: Effects in Haematological Cell Lines
Figure 4
SAHA increases the uptake of UVASens in malignant and transformed haematological cells. K562, CEM-CCRF, R100, and LCL cells were pretreated with 10 μM of SAHA for 24 hours prior to 2 hour incubation with either 1 or 5 μM UVASens, and the uptake of drug was measured by the fluorescence intensity levels. Given R100 express the P-glycoprotein transporter, uptake of 1 μM of UVASens is lower compared to the other cell lines but increases with the addition of 10 μM SAHA as shown in all cell lines. Result are expressed as means ± SD, . *, ***.
