Research Article

A Green, Expeditious, One-Pot Synthesis of 3, 4-Dihydropyrimidin-2(1H)-ones Using a Mixture of Phosphorus Pentoxide-Methanesulfonic Acid at Ambient Temperature

Table 2

Optimization of reaction conditions for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones (4k) with 4-chlorobenzaldehyde.

EntryReagentSolventConditionTimeYield (%)

1Eaton’s reagentEthanolRT, stir2.3 h60
2Eaton’s reagentEthanolReflux2 h65
3Eaton’s reagent Solvent free RT, stir5 min85