Pharmacokinetics and Biodistribution Study of 7A7 Anti-Mouse Epidermal Growth Factor Receptor Monoclonal Antibody and Its Fragment in an Immunocompetent Mouse Model
Figure 2
Plasma clearance of 125I-7A7 mAb in C57BL6 mice. 125I-7A7 mAb (2.8 mg per Kg/12.0 MBq/mg) was injected i.v. into C57BL6 mice. Blood samples were collected at time intervals (1, 10, and 30 min and 1, 4, 8, 12, 24, and 48 h post-injection) and immediately mixed with 1 mL of 0.1% BSA solution and TCA, and radioactivity was counted. Plasma activity measured in the percentage of dose per milliliter (% D/mL) (a) or 125I-7A7 mAb plasma concentration (b) is shown. Plotted values represent mean of 3 animal’s data points per group ± standard deviation (SD).
