Research Article
Pharmacokinetics of Single-Dose and Multi-Dose of Lovastatin/Niacin ER Tablet in Healthy Volunteers
Table 3
Stability of NA, NAM, NUA, and lovastatin under different storage conditions (
).
| | Storage conditions | Drug | Concentration | | Nominal | Mean found |
| | Stability at room temperature for 8 h | NA | 0.00984 | 0.00904 ± 0.00059 | | 8.86 | 8.51 ± 0.10 | | NAM | 0.0102 | 0.00948 ± 0.00007 | | 9.14 | 9.11 ± 0.07 | | NUA | 0.00993 | 0.0105 ± 0.0007 | | 8.94 | 9.81 ± 0.13 | | Lovastatin | 0.1034 | 0.09808 ± 0.0117 | | 36.19 | 37.15 ± 3.08 |
| | Stability at −80°C for 2 months | NA | 0.00984 | 0.00904 ± 0.00031 | | 8.86 | 0.00953 ± 0.00052 | | NAM | 0.0102 | 0.00925 ± 0.00072 | | 9.14 | 8.49 ± 0.18 | | NUA | 0.00993 | 8.53 ± 0.17 | | 8.94 | 8.79 ± 0.12 | | Lovastatin | 0.1034 | 0.1014 ± 0.0009 | | 36.19 | 34.10 ± 1.81 |
| | Freeze-thaw stability | NA | 0.00984 | 0.00872 ± 0.00036 | | 8.86 | 7.98 ± 0.13 | | NAM | 0.0102 | 0.0109 ± 0.0002 | | 9.14 | 8.76 ± 0.22 | | NUA | 0.00993 | 0.0108 ± 0.0003 | | 8.94 | 8.46 ± 0.24 | | Lovastatin | 0.1034 | 0.09911 ± 0.0051 | | 36.19 | 34.71 ± 1.39 |
| | Autosampler stability at 4°C for 24 h | NA | 0.00984 | 0.00955 ± 0.00096 | | 8.86 | 8.86 ± 0.16 | | NAM | 0.0102 | 0.0100 ± 0.0001 | | 9.14 | 9.58 ± 0.30 | | NUA | 0.00993 | 0.0100 ± 0.0010 | | 8.94 | 9.77 ± 0.139 | | Lovastatin | 0.1034 | 0.09931 ± 0.00437 | | 36.19 | 40.19 ± 0.31 |
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