Chromatography Research International

Research Article

Pharmacokinetics of Single-Dose and Multi-Dose of Lovastatin/Niacin ER Tablet in Healthy Volunteers

Table 7

The pharmacokinetic variables of lovastatin in volunteers after multi-dose administration of three different formulations of lovastatin/niacin ER (mean ± SD).
VariableOne Lovastatin/niacin ER tablet (500/20)Two Lovastatin/niacin ER tablets (375/10)Two Lovastatin/niacin ER tablets (500/10)
(h)1.3 ± 0.60.9 ± 0.31.3 ± 0.4
(ng/mL)10.25 ± 3.1210.45 ± 3.8512.67 ± 6.09
(ng/mL)0.02719 ± 0.028790.03676 ± 0.025530.05462 ± 0.02128
(ng/mL)1.244 ± 0.4271.389 ± 0.4111.552 ± 0.567
DF8.42 ± 1.487.51 ± 1.377.98 ± 1.39
AUC0–24 (ng·h/mL)29.85 ± 10.2533.33± 9.8637.25 ± 13.61
(h)4.6 ± 1.44.7 ± 1.15.8 ± 1.5
(h−1)0.167 ± 0.0650.155 ± 0.0430.127 ± 0.035
(L/h)742.8 ± 247.2667.3 ± 269.4616.8 ± 263.6
(L)5001.4 ± 2196.64556.9 ± 1911.95122.4 ± 2488.6