Synergistic Effect between Maternal Infection and Adolescent Cannabinoid Exposure on Serotonin 5HT<sub>1A</sub> Receptor Binding in the Hippocampus: Testing the “Two Hit” Hypothesis  for the Development of Schizophrenia

<table>Experimental design. Vertical arrows indicate time-points of administration of poly I:C on embryonic day (ED) 15 to pregnant dams (first hit), administration of the cannabinoid, HU210, to offspring for 14 days beginning on postnatal day 35 (second hit), and euthanasia of offspring on postnatal day 55, 65, or 90.</table>

International Scholarly Research Notices

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Figure 1

Figure 1: Synergistic Effect between Maternal Infection and Adolescent Cannabinoid Exposure on Serotonin 5HT<sub>1A</sub> Receptor Binding in the Hippocampus: Testing the “Two Hit” Hypothesis  for the Development of Schizophrenia 

Figure 1 | Synergistic Effect between Maternal Infection and Adolescent Cannabinoid Exposure on Serotonin 5HT1A Receptor Binding in the Hippocampus: Testing the “Two Hit” Hypothesis  for the Development of Schizophrenia 