International Scholarly Research Notices / 2012 / Article / Tab 1 / Review Article
Lipoidal Soft Hybrid Biocarriers of Supramolecular Construction for Drug Delivery Table 1 Comparison of few aspects of lipoidal particulate carriers and their applications.
S. no. Carrier Composition Entrapped agent Unique features References 1 Liposomes Phospholipids:cholesterol:alcohol Antibiotics, antineoplastic agents, antitubercular drugs Amphiphilic nature provides solubilization of both hydrophilic and lipophilic drugs, internalisation and amplification of bioactives [20 , 21 ] 2 Transfersomes Phospholipids:edge activators:alcohols:buffering agent:dye NSAIDs, anesthetics, steroidal hormones Ultradeformable vesicles can deform and pass through narrow constriction (from 5 to 10 times less than their own diameter) without measurable loss [22 –30 ] 3 Pharmacosomes Phospholipids:dichloromethane NSAIDs Colloidal dispersions of drugs covalently bound to lipids, which increased entrapment efficiency; no loss of drug due to leakage, no problem of drug incorporation [31 –33 ] 4 Ethosomes Phospholipids:ethanol Antifungal agent, antiviral agent, antikeratinizing agent, NSAIDs Combinational approach of high concentration of ethanol along with phospholipids synergizes effect of deeper distribution and penetration of drugs in the skin [17 , 34 –42 ]