Elimination of the Actin-Binding Domain in Kelch-Like 1 Protein Induces T-Type Calcium Channel Modulation Only in the Presence of Action Potential Waveforms
Figure 5
Changes in the afterhyperpolarization slope restore the ΔKelch effect, increasing Ca2+ influx through 3.2. (a) SQAP with afterhyperpolarization slopes of 20 mV/ms (blue), 0.75 mV/ms (black), and 0.35 mV/ms (orange). (b) Percentage of increase in calcium influx with the three waveforms with respect to control; the magnitude of the changes induced by the original APWs is shown with dotted lines (; ); .