Research Article

Antimicrobial or Subantimicrobial Antibiotic Therapy as an Adjunct to the Nonsurgical Periodontal Treatment: A Meta-Analysis

Table 8

Forest plot (meta-analysis, random effect model) indicating the cumulative effect sizes for probing depth reduction at sites with moderate periodontitis (4–6 mm).

PD reduction at sites with moderate periodontitis (4–6 mm) Std diff in means and 95% CI
StudyAntibioticPlaceboStd diff in means
95% Cl
Z value   value

Caton et al., 2000 [10]90930.2441.6470.100581207.tab.005
Preshaw et al., 2004 [12]10100.0810.5840.560
Novak et al., 2002 [11]1071021.2962.6340.008
Mohammad et al., 2005 [8]66760.5303.0960.002
Guerrero et al., 2005 [14]20210.7872.4260.015
Needlerman et al., 2007 [16]1618−0.44−1.2750.202
Synthesis3093200.2773.4350.001

PD: probing depth, , confidence level 95%.