Studies on Paliperidone in OROS Tablets: Extraction Procedure and Chromatographic Analysis

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr class="thead"><td align="left"> Condition</td><td align="center">Reference</td><td align="center">Variation</td></tr><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr><td align="left">pH of aqueous solvent</td><td align="center">3.8</td><td align="center">3.6; 4.0</td></tr><tr><td align="left">Concentration of organic solvent (%)</td><td align="center">30.0</td><td align="center">28.0; 32.0</td></tr><tr><td align="left">Flow rate (mL min<sup>−1</sup>)</td><td align="center">1.0</td><td align="center">0.8; 1.2</td></tr><tr><td align="left">Column supplier</td><td align="center">Shim-pack C18, 25 cm</td><td align="center">ODS-Hypersil, 25 cm</td></tr><tr class="table-tr"><td colspan="3"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Factors used during robustness testing applied to LC analysis of paliperidone in extended-release OROS tablets.

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Table 1: Studies on Paliperidone in OROS Tablets: Extraction Procedure and Chromatographic Analysis 