Research Article
Stability Indicating Method for Simultaneous RP HPLC Determination of Camylofin Dihydrochloride and Nimesulide in Pharmaceutical Preparations
Table 11
Forced degradation for Camylofin dihydrochloride.
| | Stress condition | Time | % assay of camylofin 2HCl | Degradation (%) w.r.t. control | Purity angle | Purity threshold | Peak Purity |
| | Control sample | NA | 100.1 | NA | 0.220 | 0.250 | Passes | | Acid hydrolysis (1 M HCl) | 48 h | 89.2 | 10.9 | 0.220 | 0.252 | Passes | | Base hydrolysis (0.05 N NaOH) | 12 h | 78.9 | 21.2 | 0.199 | 0.240 | Passes | | Oxidation (3% H2O2) | 48 h | 90.1 | 10.1 | 0.204 | 0.248 | Passes | | Thermal (105°C) | 5 days | 92.5 | 7.6 | 0.218 | 0.254 | Passes | | Light (photolytic degradation) | 10 days | 94.5 | 5.6 | 0.217 | 0.251 | Passes |
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