Research Article
Stability Indicating Method for Simultaneous RP HPLC Determination of Camylofin Dihydrochloride and Nimesulide in Pharmaceutical Preparations
Table 12
Forced degradation for nimesulide.
| | Stress condition | Time | % Assay of camylofin 2HCl | Degradation (%) w.r.t. control | Purity angle | Purity threshold | Peak purity |
| | Control sample | NA | 100.5 | NA | 0.184 | 0.200 | Passes | | Acid hydrolysis (1 M HCl) | 48 h | 96.4 | 4.1 | 0.182 | 0.200 | Passes | | Base hydrolysis (0.05 N NaOH) | 12 h | 82.5 | 18.0 | 0.189 | 0.201 | Passes | | Oxidation (3% H2O2) | 48 h | 97.1 | 3.4 | 0.179 | 0.200 | Passes | | Thermal (105°C) | 5 days | 94.1 | 6.4 | 0.180 | 0.205 | Passes | | Light (photolytic degradation) | 10 days | 90.1 | 10.4 | 0.187 | 0.204 | Passes |
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