Stability Indicating Method for Simultaneous RP HPLC Determination of Camylofin Dihydrochloride and Nimesulide in Pharmaceutical Preparations

<table class="table-group" id="tab9"><tr><td><table class="table"><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr class="thead"><td align="left" rowspan="3">Parameters</td><td align="center" colspan="2">Low organic composition</td><td align="center" colspan="2">High organic composition</td></tr><tr class="thead"><td align="center" colspan="2">(Buffer solution pH 5.0 : MeOH::630 : 370)</td><td align="center" colspan="2">(Buffer solution pH 5.0 : MeOH::570 : 430)</td></tr><tr class="thead"><td align="center">Camylofin dihydrochloride</td><td align="center">Nimesulide</td><td align="center">Camylofin dihydrochloride</td><td align="center">Nimesulide</td></tr><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr><td align="left">Resolution</td><td align="center">5.11</td><td align="center">19.24</td><td align="center">4.30</td><td align="center">17.25</td></tr><tr><td align="left">% assay</td><td align="center">99.7</td><td align="center">100.2</td><td align="center">100.3</td><td align="center">100.4</td></tr><tr class="table-tr"><td colspan="5"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Results of robustness experiment: change of mobile phase composition.

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Table 9

Table 9: Stability Indicating Method for Simultaneous RP HPLC Determination of Camylofin Dihydrochloride and Nimesulide in Pharmaceutical Preparations 

Table 9 | Stability Indicating Method for Simultaneous RP HPLC Determination of Camylofin Dihydrochloride and Nimesulide in Pharmaceutical Preparations 