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Age/sex/history | Published/author | Location of GISTs | Primary symptom | Tumor size (cm) | Primary treatment | Immunohistochemistry/mutational analysis | Pathology | Postop. imatinib/sunitinib treatment | Relapse |
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25 y.o./F | 1/2009/Scherjon et al. [17] | Duodenum | Palpable mass | ; | Surgical | (+) CD117/c-kit; weakly (+) MS-actin and SM-actin | Spindle cells | No | Yes, 6 years after surgery |
74 y.o./F | 1/2009/Terada [8] | Uterus | Pelvic pain | | Surgical | (+) CD117/c-kit; weakly (+) PDGFRA | Spindle cell | Yes (I) | No, 2 years after treatment |
52 y.o./F | 11/2009/Trabelsi et al. [18] | Pancreas | Epigastric pain | | Surgical | (+) CD117/c-kit; (+) CD34 | Mixed Spindle-epithelioid cells | No | No, 10 months after surgery |
58 y.o./F | 1/2008/Papaspyros and Papagiannopoulos [19] | Esophagus | Pleuritic chest pain | 10 in dia. | Surgical | (+) CD117/c-kit; (+) CD34 | Spindle-shaped cells; >5/50 hpf | Not reported | Not reported |
65 y.o./F | 10/2005/Lin et al. [20] | Gastric corpus | Incidental finding | | Surgical | (+) CD117/c-kit; (+) CD34; (+) NSE; (+) S-100 | Not reported | No | No, 28 mos. after surgery |
66 y.o./M | 8/2007/Efstathios et al. [21] | Small bowel | Small bowel obstruction | 10 in dia | Surgical | (+) CD117/c-kit; (+) SMA, (+) S-100 | Spindle-shaped cells; 8–10/hpf | Yes (I) | Yes, 2 years after treatment |
60 y.o./F/NF-1 | 2010/Ohtake et al. [22] | Multiple jejenum/duodenum | Incidental finding | 1.4 dia. | Surgical | (+) CD117/c-kit; (+) CD34 | Spindle-shaped cells/<5/50/hpf | No | No, 2 years after surgery |
34 y.o./F | 5/2009/Masoodi et al. [23] | Transverse colon | Abdominal lump | 8.0 in dia. | Surgical/conventional chemotherapy | (+) CD117/c-kit | Spindle shaped/no mitotic activity | No | No, 8 months after treatment |
75 y.o./M | 5/2008/Laperouse et al. [9] | Body of stomach | GI bleed | | Surgery | (+) CD117/c-kit; (+) CD34, (+) desmin | Spindle-shaped cells; <5/50/hpf | Yes (I) | Not reported |
68 y.o./M | 10/2004/Demetri et al. [7] | Retroperitoneum contiguous with post. wall stomach, pancreas, multiple liver mass | Incidental finding | 13 in dia. | Surgery | (+) CD117/c-kit; (+) CD34 | Spindle-shaped cells/low mitotic rate | Yes (I) initially then (S) | Not reported |
54 y.o./M | 02/2010/Freeman et al. [24] | Greater curvature of stomach | Upper Abdominal pain | 1.3 on dia. | Surgery | (+) CD117/c-kit | 10/hpf | Yes (I) | No, 18 months after treatment |
42 y.o./F | 4/2007/Pinto et al. [25] | Small bowel | Lower abdominal pain | 4.8 in dia | Surgery | (+) CD117/c-kit; (+) CD34 | Spindle-shaped cell; 9/50 hpf | Yes (I) | No, 16 months after treatment |
76 y.o./F | 4/2007/Pinto et al. [25] | Stomach | Dysuria, altered bowel movement, abdominal discomfort | 17 in dia. | Surgery | (+) CD117/c-kit; (+) CD34 | Spindle-shaped cell; 7/50 hpf mitotic index | No | No, 12 months after treatments |
61 y.o./F | 6/2011/Fan et al. [26] | Rectum | Lower GI bleed | 8.0 in dia | Surgery | (+) CD117/c-kit; (+) CD34; (+) SMA | 5/50 hpf mitotic index | No | Not reported |
17 y.o./M | 08/2009/Luo et al. [27] | R liver lobe | Incidental finding | | Radiofrequency ablation | (+) CD117/c-kit; (+) CD34; (+) vimentin | Spindle cells/no mitosis | No | No, 3 mos. after treatment |
28 y.o./M | 07/2010/Yucel et al. [28] | Duodenum | Abdominal pain | 24 in dia. | Surgery | (+) CD117/c-kit; (+) CD34 | 0/50 hpf mitotic index | No | Not reported |
62 y.o./M | 07/2010/Yucel et al. [28] | Fundus of stomach | Abdominal pain | 10 in dia | Surgery | (+) CD117/c-kit; (+) CD34 | <5/50 hpf mitotic index | No | Not reported |
38 y.o./M | 07/2010/Yucel et al. [28] | Jejunum | Abdominal pain, rectal bleeding | 2.5 in dia. | Surgery | (+) CD117/c-kit; (+) CD34 | <1/50 hpf mitotic index | No | Not reported |
62 y.o./M | 01/2009/Lee et al. [29] | Stomach | Symptomatic anemia | Not reported | Surgery | (+) CD117/c-kit | Spindle-shaped cells; 60/50 hpf | Yes (I) | Yes, Increase in tumor size, liver 2 years after therapy |
80 y.o./M | 2011/Theodosopoulos et al. [30] | Stomach | Epigastric discomfort, nausea, weight loss | 3.0 in dia. | Surgery | (+) CD117/c-kit | Severe nuclear atypia; 6/50 hpf mitotic index | Yes (I) | No, 1 year after treatment |
52 y.o./F | 12/2009/Ulusan et al. [31] | Small intestine | Abdominal pain | | Surgery | (+) CD117/c-kit; weakly (+) S-100, SMA, CD34 | 3/50 hpf mitotic index | Yes (I) | Not reported |
31 y.o./F | 06/2003/Sakamoto et al. [32] | Duodenum/pancreas | Not mentioned | Not reported | Surgery | (+) CD117/c-kit | Low-grade malignant potential | No | Not reported |
28 y.o./F | 2010/Abdel-Ghaffar [33] | Mesentery | Abdominal pain, distention | | Surgery | (+) CD117/c-kit; (+) CD34 | Spindle-shaped cells with twisted nuclei; 7/50 hpf | No | No, 3 years after treatment |
65 y.o./M | 06/2007/Todoroki et al. [34] | Greater omentum | Abdominal mass | | Surgery | (+) CD34; weakly (+) CD117/c-kit; PDGFA gene mutation on exon 12 | Mixed spindle-epitheloid; 2/50 hpf | Yes | No, 6 months after treatment |
38 y.o./M | 06/2011/Dhull et al. [35] | Jejunum | Abdominal pain/abdominal fullness | | Surgery | (+) CD117/c-kit | Spindle-shaped cells; high grade stromal tumor | Yes (I) | No, 6 months after therapy |
65 y.o./F | 3/2008/Dickhoff et al. [36] | Rectum | Abdominal pain | 15 in dia. | Surgery | (+) CD117/c-kit | High mitotic rate | No | Yes, 1 year after |
62 y.o./M | 3/2008/Dickhoff et al. [36] | Rectum, metastatic | Obstipation, voiding problem | | Imatinib | (+) CD117/c-kit | High mitotic rate | N/A | No, regression of tumor on ff up |
55 y.o./M/NF-1 | 11/2009/Takeuchi et al. [37] | Duodenum | Incidental finding | | Surgery | (+) CD117 c-kit/(+) CD34, | Spindle-shaped cells; 3/50 hpf | No | No, after 2 years |
56 y.o./F | 3/2010/Tahara et al. [38] | Lesser curvature of gastric corpus | Abdominal pain, nausea, anemia | | Surgery | (+) CD117 c-kit/(+) CD34 | Spindle-shaped cells; 0/50 hpf | No | No, after 18 mos. |
66 y.o./F/NF-1 | 10/2010/Kitagawa et al. [39] | Jejunum | Partial seizures | 6.0 in dia. | Surgery | (+) CD117/c-kit/wild type KIT | Spindle-shaped cells; 5/50 hpf | No | Not reported |
70 y.o./M/NF-1 | 5/2011/Takakura et al. [40] | Jejunum | Melena, fatigue | | Surgery | (+) CD117/c-kit/(+) CD34 | Spindle-shaped cell; low mitotic activity | No | Not reported |
28 y.o./F | 2010/Varras et al. [41] | Small intestine | Abdominal pain | | Surgery | (+) CD117/c-kit/(+) CD34 | Mixed spindle-epithelioid; 5/50 hpf | Yes (I) | No, 3 years after |
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