Time-Dependent Changes of Plasma Concentrations of Angiopoietins, Vascular Endothelial Growth Factor, and Soluble Forms of Their Receptors in Nonsmall Cell Lung Cancer Patients Following Surgical Resection
Table 1
The plasma concentration of Ang1, Ang2, sTie2, VEGF, and sVEGF R1 in controls and lung cancer patients before and after surgical treatment (median, 25–75 percentile).
Controls
Lung cancer
Before
After 7
After 30
value
Median
Median
Median
Median
(25–75 percentile)
(25–75 percentile)
(25–75 percentile)
(25–75 percentile)
Ang1 [pg/mL]
976.7 (0.0–2094.5)
5682.0 (3118.9–8939.4)
7496.6 (3266.0–11100.0)
5279.1 (990.7–8054.1)
Ang2 [pg/mL]
1668.3 (1291.4–2139.7)
2501.3 (2138.7–2645.4)
3688.7 (2414.1–4841.70)
2858.2 (2177.2–3502.6)
*
**
***
sTie2 [pg/mL]
15788 (11975–30534)
24806 (16545–28939)
22567 (16859–26375)
25 318 (21584–33965)
*
VEGF [pg/mL]
66.1 (38.6–99.4)
124.4 (66.6–251.5)
238.5 (113.3–521.6)
115.5 (42.9–91.0)
*
sVEGF-R1 [pg/mL]
107.8 (86.1–122.9)
95.9 (83.7–120.8)
94.7 (83.0–113.3)
95.9 (88.4–121.6)
Before: before surgical treatment; After 7: on day 7 after treatment; After 30: on day 30 after treatment.
*Before versus after 7; **after 7 versus after 30; ***before versus after 30.
