International Scholarly Research Notices

Research Article

Method Development and Validation of Darifenacin in Rat Plasma by Liquid Chromatography-Tandem Mass Spectrometry: Application to a Pharmacokinetic Study

Table 4

Mean pharmacokinetic parameters of darifenacin in rat plasma after intravenous administration of 0.27 mg/200 g male rat.
Pharmacokinetic parameterDarifenacin
AUC0–t (pg·h/mL)28961.88
(pg/mL)9109
AUC0–∞ (pg·h/mL)29847.67
Kel (h−1)0.14225
(h)0.25
AUC0–∞: area under the curve extrapolated to infinity, AUC0–t : area under the curve up to the last sampling time, : the maximum plasma concentration, : the time to reach peak concentration, Kel: the apparent elimination rate constant.