Research Article

Reduction of Oxygen-Carrying Capacity Weakens the Effects of Increased Plasma Viscosity on Cardiac Performance in Anesthetized Hemodilution Model

Table 1

Hct, Hb, and rheological properties after complete hemodilution.

GroupHct (%)Hb (g/dL)Blood viscosity (cP)Plasma viscosity (cP)Plasma COP (mmHg)
1HD2HD1HD2HD1HD2HD1HD2HD1HD2HD

Blood (baseline)52 ± 215.6 ± 0.74.7 ± 0.61.1 ± 0.116 ± 2
Dx2M27 ± 2*17 ± 2*,†,‡8.3 ± 0.7*5.2 ± 0.8*,†,‡3.6 ± 0.2*,‡3.0 ± 0.1*,†,‡2.1 ± 0.1*,‡2.0 ± 0.1*,‡18 ± 217 ± 4
Dx7027 ± 2*22 ± 1*,†8.2 ± 0.6*6.7 ± 0.5*,†3.1 ± 0.1*2.6 ± 0.3*,†1.3 ± 0.1*1.4 ± 0.1*16 ± 117 ± 2

The values of Hct, Hb and rheological properties of blood and plasma at the baseline and after complete the 1-step hemodilution (1HD) and the 2-step hemodilution (2HD). Viscosity was measured at shear rate of 160 1/sec at 37°C. Values are means ± SD. 𝑃 < 0 . 0 5 compared with baseline, 𝑃 < 0 . 0 5 compared with the 1-step hemodilution using same plasma expander. 𝑃 < 0 . 0 5 compared with Dx70 in the same step hemodilution.