Clinical Study

Flow-Mediated Vasodilation Is Not Attenuated in Hypertensive Pregnancies Despite Biochemical Signs of Inflammation

Table 2

(a) FMD during pregnancy and postpartum, data are expressed as means, (minimums, maximums) and standard deviations. Normal pregnancies compared to hypertensive pregnancies

FMD (%) 𝑃
PregnancyPostpartum

Control group ( 𝑁 = 3 2 / 2 4 )8.8 (−1.5–21) ± 5.17.9 (2.9–16) ± 3.5 𝑃 = 0 . 4 3 9
Hypertensive pregnancies ( 𝑁 = 2 6 / 1 6 )11 (−2.9–24) ± 6.38.0 (1.6–16) ± 4.2 𝑃 = 0 . 1 0 5
P 𝑃 = 0 . 1 9 4 𝑃 = 0 . 9 7 8

(b) FMD in normal, hypertensive end preeclamptic women during pregnancy and postpartum. The mean, minimums, maximums, and standard deviations

Mean baseline diameter of the a. brachialis in pregnancy (mm)Mean FMD during pregnancy %Mean FMD in nitrotest during pregnancyMean baseline diameter of the a. brachialis postpartum (mm)Mean FMD postpartum %Mean FMD in nitro test postpartum

Normal pregnancy ( 𝑁 = 3 2 / 2 4 )0.33 (0.27–0.43) ± 0.048.8%22%0.30 (0.25–0.38) ± 0.037.9%26%

Hypertensive pregnancy ( 𝑁 = 1 4 / 9 )0.35 (0.30–0.45) ± 0.0410%19%0.32 (0.29–0.36) ± 0.038.5%26%

Preeclamptic pregnancies ( 𝑁 = 1 2 / 7 )0.31 (0.24–0.34) ± 0.0311%21%0.30 (0.25–0.34) ± 0.047.2%28%

Difference btw the groupsHT versus PE
𝑃 = 0 . 0 0 8
NS/HT versus PE 𝑃 = 0 . 0 0 3 NSNSNS/NSNS

pregnancy versus postpartumControl 𝑃 < 0 . 0 0 1 , HT 𝑃 = 0 . 0 0 1 , PE NSPE 𝑃 = 0 . 0 4 Control 𝑃 = 0 . 0 0 5 HT 𝑃 < 0 . 0 0 1 PE 𝑃 = 0 . 0 0 4

(c) FMD during pregnancy and postpartum. Means, minimums, and maximums and SDs

PregnancyPostpartum 𝑃

Brachial artery diameter at rest (cm)Control ( 𝑁 = 3 2 / 2 4 )0.33 (0.27–0.43) ± 0.040.30 (0.25–0.38) ± 0.03 <0.001*
Hypertensive ( 𝑁 = 2 6 / 1 6 )0.33 (0.24–0.45) ± 0.040.31 (0.25–0.36) ±0.03 0.011*
P0.9880.534

Endothelium dependent vasodilation, FMD% (%)Control ( 𝑁 = 3 2 / 2 4 )8.8 (−1.5–21) ± 5.17.9 (2.9–16) ± 3.50.439
Hypertensive ( 𝑁 = 2 6 / 1 6 )11.0 (−2.9–24) ± 6.38.0 (1.6–16) ± 4.20.105
P0.1940.978

Endothelium independent vasodilation, NTG (%)Control ( 𝑁 = 3 2 / 2 4 )22%26% 0.005*
Hypertensive ( 𝑁 = 2 6 / 1 6 )20%28% <0.001*
𝑃 0.2210.421

*: 𝑃 value < 0 . 0 5 .