Research Article

Use of Response Surface Methodology in the Formulation and Optimization of Bisoprolol Fumarate Matrix Tablets for Sustained Drug Release

Table 4

Results of experiments to assure optimization capability.

CodeCalcium alginate (mg) 
HPMC K4M (mg)  
Carbopol 943 (mg) 
Responses
6h (%)aHardness (kg/cm2)

F-O15.2832.1230.31 Actual valuesb
41.61 ± 1.974.65 ± 0.07
Predicted values
40.004.54

% Errorc4.032.42

a 6h (%): cumulative drug release after 6 hours; bactual values = mean ± S.D., = 3; c% error = (actual value − predicted value)/predicted value × 100; , , and represent the main effects (factors).