Oral Metformin Treatment Prevents Enhanced Insulin Demand and Placental Dysfunction in the Pregnant Rat Fed a Fructose-Rich Diet
Figure 1
Circulating glucose (d) and insulin (c) levels before (sample time zero), and several times after i.v. glucose (2 g/Kg BW) administration in 14-day-pregnant ND (open circles), FRD (closed circles), MF + ND (open squares), MF + FRD (closed squares), and ND + SUR (closed triangles) rats. The areas under the curves (AUC) of plasma glucose (b) and insulin (d) concentrations throughout the test are also displayed. (Values are means ± SEM, dams per group). * versus ND.
