Oral Metformin Treatment Prevents Enhanced Insulin Demand and Placental Dysfunction in the Pregnant Rat Fed a Fructose-Rich Diet

<table>Representative placental mesometrial triangle (MMT) area of implanted offspring in 20-day-pregnant ND (a), FRD (c), MF + ND (b), MF + FRD (d), and ND + SUR (e) rats stained with PAS (L: labyrinth; Bars: 200 <i>μ</i>m). Arrows show vessel area (×4). Insets: corresponding MMT area at a higher magnification (10x). Maternal vessel area (in percentage) on gestational day 20 in the different groups of dams (f; values are means ± SEM, <svg height="11.0375" id="M67" style="vertical-align:-0.27588pt" version="1.1" viewbox="0 0 35.099998 11.0375" width="35.099998" xmlns="http://www.w3.org/2000/svg">
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<tspan style="font-size: 12.50px; " x="0" y="0">𝑛</tspan>
<tspan style="font-size: 12.50px; " x="9.6773224" y="0">=</tspan>
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</svg> specimens per group). *<svg height="11.25" id="M68" style="vertical-align:-0.30096pt" version="1.1" viewbox="0 0 56.150002 11.25" width="56.150002" xmlns="http://www.w3.org/2000/svg">
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<tspan style="font-size: 12.50px; " x="0" y="0">𝑃</tspan>
<tspan style="font-size: 12.50px; " x="10.890113" y="0">&lt;</tspan>
<tspan style="font-size: 12.50px; " x="22.930502" y="0">0</tspan>
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<tspan style="font-size: 12.50px; " x="32.307751" y="0">0</tspan>
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</svg> versus ND values.</table>

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fig2

Figure 2

Figure 2: Oral Metformin Treatment Prevents Enhanced Insulin Demand and Placental Dysfunction in the Pregnant Rat Fed a Fructose-Rich Diet 