Research Article

Oral Metformin Treatment Prevents Enhanced Insulin Demand and Placental Dysfunction in the Pregnant Rat Fed a Fructose-Rich Diet

Table 1

Body weight values (BW, in grams) of dams, recorded on gestational day (Gd) zero, fourteen, and twenty. The percent of increase in BWs (in accordance with corresponding BWs on Gd 0) on Gd 14 and Gd 20 is also depicted. Values are means ± SEM (n = 14/16 rats on Gd 0; n = 7/8 rats on Gd 14 and Gd 20).

BW Gd 0BW Gd 14% increase Gd 14BW Gd 20% increase Gd 20

ND246.2  ±  9.9286.5  ±  9.616.8  ±  2.9342.5  ±  13.938.9  ±  3.5
FRD241.1  ±  6.1286.9  ±  6.819.9  ±  2.1346.6  ±  11.743.2  ±  2.1
ND + MF245.9  ±  7.2286.8  ±  6.216.9  ±  2.5345.5  ±  14.440.3  ±  2.4
FRD + MF228.8  ±  5.7273.8  ±  3.319.9  ±  2.6338.9  ±  9.344.1  ±  5.1
SUR + ND244.9  ±  5.9273.6  ±  6.714.2  ±  1.9326.8  ±  12.933.4  ±  3.5