Application of a Reliable LC-MS/MS Method for Determination of Rizatriptan in Healthy Subject Samples: Demonstration of Assay Reproducibility by Incurred Sample Reanalysis

<table class="table-group" width="800px"><tr class="fig-image" id="a"><td><img alt="761679.fig.003a" src="https://static.hindawi.com/articles/isrn/volume-2012/761679/figures/761679.fig.003a.jpg"/></td></tr><tr class="fig-caption"><td align="center"><table><tr><td><b>(a) </b>  XIC of +MRM (2 pairs): 270.1/201.2 amu</td></tr></table></td></tr><tr class="fig-image" id="b"><td><img alt="761679.fig.003b" src="https://static.hindawi.com/articles/isrn/volume-2012/761679/figures/761679.fig.003b.jpg"/></td></tr><tr class="fig-caption"><td align="center"><table><tr><td><b>(b) </b> XIC of +MRM (2 pairs): 296.1/58.1 amu</td></tr></table></td></tr></table>

<table>Representative postcolumn analyte infusion MRM LC-MS/MS overlaid chromatograms for rizatriptan and sumatriptan. (a) Exact ion current (XIC) chromatogram of rizatriptan (<i>m/z</i> 270.1 → 201.2); (b) XIC of sumatriptan (IS, <i>m/z</i> 296.1 → 58.1). </table>

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Figure 3: Application of a Reliable LC-MS/MS Method for Determination of Rizatriptan in Healthy Subject Samples: Demonstration of Assay Reproducibility by Incurred Sample Reanalysis 

Figure 3 | Application of a Reliable LC-MS/MS Method for Determination of Rizatriptan in Healthy Subject Samples: Demonstration of Assay Reproducibility by Incurred Sample Reanalysis 