International Scholarly Research Notices

Research Article

Application of a Reliable LC-MS/MS Method for Determination of Rizatriptan in Healthy Subject Samples: Demonstration of Assay Reproducibility by Incurred Sample Reanalysis

Table 1

Intrabatch and interbatch accuracy and precision for rizatriptan.
QC ID Conc. added
(ng/mL)		Intra-batchInter-batch
Mean conc. found
(ng/mL)a		Accuracy (%)CV (%) Mean conc. found
(ng/mL)b		Accuracy (%)CV (%)
LLOQ0.2060.20100.05.0180.1995.08.4
LQC0.6060.60100.02.5180.5896.75.0
MQC-25.0064.7494.83.8184.7895.62.4
MQC-124.00622.9295.52.41822.7694.82.0
HQC45.00643.0295.62.01843.4496.52.5
ULOQ60.00656.4294.04.51857.2595.43.1
: total number of observations.
CV: coefficient of variation.
aMean of six replicate observations at each concentration.
bMean of eighteen replicate observations over three different analytical runs.