Application of a Reliable LC-MS/MS Method for Determination of Rizatriptan in Healthy Subject Samples: Demonstration of Assay Reproducibility by Incurred Sample Reanalysis
Table 5
Salient features of the present method in comparison with reported procedures for determination of rizatriptan.
Sr. number
Detection technique; LLOQ
Extraction technique; plasma volume for processing
Retention time; run time; maximum on-column loading at ULOQ per injection volume
Organic solvent consumption (extraction and chromatography) per sample analysis
aIn plasma of dogs; balong with sumatriptan; cin human serum along with zolmitriptan, naratriptan, and sumatriptan; LLOQ: lower limit of quantitation; ULOQ: upper limit of quantitation; SPE: solid phase extraction; LLE: liquid-liquid extraction; NA: data not available; PM: present method.