Research Article

Stratification of Highest-Risk Patients with Chronic Skin Ulcers in a Stanford Retrospective Cohort Includes Diabetes, Need for Systemic Antibiotics, and Albumin Levels

Table 2

Clinical risk factors1,2 associated with non-healing wounds3.

Healing wound ( )Nonhealing wound ( ) value

Diabetes mellitus (%)28/68 (41.8%)55/67 (82.1%)<0.001*
Peripheral neuropathy (%)28/66 (42.4%)51/67 (76.1%)<0.001*
Renal insufficiency (%)21/67 (31.3%)36/67 (53.7%)0.008*
Peripheral arterial disease (%)35/67 (52.2%)48/65 (73.8%)0.02*
Venous stasis (%)32/65 (49.2%)21/63 (33.3%)0.067
Congestive heart failure (%)23/65 (35.3%)24/61 (39.3%)0.65
Immunosuppression3 (%)15/67 (22.4%)13/68 (19.1%)0.64
Nondermatologic malignancy4 (%)6/68 (8.9%)3/67 (4.4%)0.49

1Presence or absence of clinical risk factors was determined coincident with or prior to diagnosis of skin wound. They were assessed by text review of charts for physician documentation and query of specific tests such as echocardiogram. Where presence or absence of risk factors could not be determined the information was recorded as missing. Actual numbers of recorded data for each risk factor are presented in the table. 2Healing wounds were those that healed within 1 year of followup. Non-healing wounds were defined as wounds that required amputation or did not heal after 1year of followup. 3Immunosuppression was defined as taking immunosuppressive medications like steroids or chemotherapy or the presence of conditions of immunocompromise such as HIV/AIDS.
4Only nondermatologic malignancies co-incident with skin wound were ascertained.
*indicates statistical significance at