Impaired angiogenic response in the ischemic hind limbs of db1 and Lepr^db/db mice. (a) Schematic time course of the study design. (b) A low perfusion signal (dark blue) was observed in the ischemic hind limb of db1 and Lepr^db/db mice, whereas a higher perfusion signal (white to red) was detected in WT mice on postoperative days 3, 7, and 14. (c) Quantitative analysis of the ischemic/nonischemic LDBF ratio in WT and db1 mice before hind limb ischemia surgery, shortly after hind limb ischemia surgery, and on postoperative days 3, 7, and 14 (). *. (d) Quantitative analysis of the ischemic/nonischemic LDBF ratio in WT and Lepr^db/db mice before hind limb ischemia surgery, shortly after hind limb ischemia surgery, and on postoperative days 3, 7, and 14 (). .