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Research Article

[Retracted] Interaction of TMPyP4, TMPyP3, and TMPyP2 with Intramolecular G-Quadruplex Formed by Promoter Region of Bcl2 and KRAS NHPPE

Table 5

ITC data of Bcl2 P1 promoter and KRAS NHPPE quadruplexes interaction with TMPyP2, TMPyP3, and TMPyP4 ligands.
ITC-derived thermodynamic parameters39Bcl2 quadruplex DNAKRAS NHPPE quadruplex DNA
TMPyP4TMPyP3TMPyP2TMPyP4TMPyP3TMPyP2
𝐾 1 × 1 0 − 8 0.3600.2560.06990.3240.2530.0578
Δ 𝐺 1 (kcal/mol)−9.16−6.87−5.97−8.32−6.35−5.73
Δ 𝐻 1 (kcal/mol)−4.24−3.97−0.60−3.82−3.46−0.57
− 𝑇 Δ 𝑆 1 (kcal/mol)−4.52−3.47−6.09−8.27−3.21−5.97
𝐾 2 × 1 0 − 6 0.91——0.87——
Δ 𝐺 2 (kcal/mol)−6.52——−6.12——
Δ 𝐻 2 (kcal/mol)−8.97——−11.52——
− 𝑇 Δ 𝑆 2 (kcal/mol)−2.94——−1.79——