Blue light reception through WCC complex. (a) WCC-mediated gene expression and various light responses in Neurospora crassa. (b) Photoreceptor proteins in Neurospora crassa. The figure shows two multidomain proteins WC-1 and WC-2 forming photoresponsive WCC complex. WC-1 interacts with WC-2 through PAS (protein-protein interaction) domains. LOV-domain (a specialized variant of the PAS domain) in photoreceptor WC-1 noncovalently binds FAD. The two proteins contain activation domains (ADs), DNA-binding Zn-finger domains, and nuclear localization domains (NLSs).