International Scholarly Research Notices

Research Article

Evaluation of Oral Robenacoxib for the Treatment of Postoperative Pain and Inflammation in Cats: Results of a Randomized Clinical Trial

Table 2

Summary statistics for secondary efficacy variables. On day 0, LOCF was applied. The treatment by time interaction was significant for all variables, therefore comparisons at each time (0.5, 1, 3, 5, and 8 hours) are reported. On days 1 and 2, data are provided without LOCF applied. Groups were not compared statistically after 8 hours.


Treatment	Time (hours)	n	Posture score			Social interaction behavior score			Soft tissue incision site pain score
			Mean	SD	P value	Mean	SD	P value	Mean	SD	P value

Summary statistics with LOCF

Robenacoxib	0	161	1.15	0.65	0.9156	1.16	0.66	0.7519	1.22	0.42	0.1092
Placebo		79	1.14	0.59		1.13	0.59		1.23	0.42
Robenacoxib	0.5	160	1.26	0.61	0.9730	1.26	0.60	0.8598	1.31	0.52	0.6441
Placebo		79	1.29	0.64		1.29	0.60		1.38	0.58
Robenacoxib	1	161	1.34	0.66	0.4257	1.36	0.69	0.4602	1.39	0.58	0.3371
Placebo		79	1.43	0.67		1.46	0.73		1.56	0.78
Robenacoxib	3	161	1.31	0.61	0.0039	1.34	0.66	0.0373	1.43	0.61	0.1095
Placebo		79	1.61	0.74		1.58	0.78		1.65	0.85
Robenacoxib	5	161	1.35	0.66	0.0002	1.37	0.68	0.0019	1.42	0.61	0.0031
Placebo		79	1.76	0.8		1.73	0.83		1.75	0.90
Robenacoxib	8	161	1.40	0.64	0.0004	1.36	0.67	0.0005	1.49	0.63	0.0087
Placebo		79	1.82	0.84		1.78	0.90		1.78	0.90

Summary statistics without LOCF

Robenacoxib	24	145	1.37	0.55	ND	1.23	0.48	ND	1.43	0.59	ND
Placebo		54	1.52	0.72		1.30	0.50		1.44	0.72
Robenacoxib	28	142	1.29	0.47	ND	1.17	0.43	ND	1.40	0.55	ND
Placebo		50	1.38	0.53		1.34	0.59		1.36	0.66
Robenacoxib	32	141	1.33	0.55	ND	1.17	0.45	ND	1.43	0.56	ND
Placebo		49	1.41	0.54		1.33	0.47		1.31	0.65
Robenacoxib	48	138	1.25	0.47	ND	1.13	0.40	ND	1.39	0.53	ND
Placebo		48	1.42	0.58		1.27	0.61		1.27	0.61
Robenacoxib	52	137	1.27	0.46	ND	1.09	0.32	ND	1.36	0.51	ND
Placebo		43	1.33	0.47		1.16	0.37		1.14	0.41

ND: not determined.