801720.fig.005a
(a)
801720.fig.005b
(b)
801720.fig.005c
(c)
Figure 5: Three-dimensional plot of the response surface for 𝑌 (found critical resolution-1 between bortezomib and Imp-C), (a) variation of the response 𝑌 as a function of A (flow rate) and B (% acetonitrile); fixed factor: C (% methanol) = 80% v/v, (b) variation of the response 𝑌 as a function of A (flow rate) and C (% methanol); fixed factor: B (% acetonitrile) = 28.5% v/v, (c) variation of the response 𝑌 as a function of B (% acetonitrile) and C (% methanol); fixed factor: A (flow rate) = 1.0 mL min−1.